Alzheimer’s Disease: Many Failures Before One Success

The Long Road To The First Disease-Modifying Alzheimer’s Drug

For Biogen/Eisai’s success with Aduhelm, there were 93 failures in the anti-amyloid field. In Vivo's sister publication Scrip took a look back at how the pipeline for amyloid-targeting Alzheimer’s drugs progressed over the past decade to showcase exactly how difficult the Alzheimer’s space has been.

Pharmaceutical research into brain disorders including dementia and alzheimer's
• Source: Alamy

While its US Food and Drug Administration approval and $56,000 price tag have been controversial, Biogen Inc./Eisai Co. Ltd.’s Aduhelm (aducanumab) still represents a lot of firsts as the first disease-modifying drug approved for Alzheimer’s disease and the first amyloid-targeting therapy to make it all the way across the drug development finish line. But it was far from the first attempt.

Scrip took a look through the history of the Alzheimer’s drug pipeline, drilling down into the anti-amyloid drug candidates, to...

In Vivo Podcast

Candid conversations with C-suite leaders.

Keep up with strategy, innovation and evolving trends across life science industries.

More from In Vivo Archive

In Partnership with Cerba Research

Prioritizing Safety in CAR-T Therapy: Patient Monitoring with Cerba Research’s Testing Portfolio

The cell and gene therapy (CGT) clinical trial landscape in general and CAR-T cell clinical trials in particular are a special focus for the FDA, EMA, and other regulatory agencies. The whole industry is thus aware of the recent FDA safety investigation and requirements for labeling CAR therapy products.

New Identifying The Barriers For Use Of Digital Clinical Trial Technologies

Digital clinical trials, a trend sparked by the COVID-19 pandemic that has held the biopharma industry’s interest, are changing the way patients interact with research and improving access, says Medable’s CEO.

Nesw Fewer Acquisitions And Alliances In 2023, But Valuations Increased

 
• By 

INFOGRAPHIC: Deal volume for both M&A and alliances fell in 2023, but average valuations rose appreciably. Antibody-drug conjugates for cancer drove high-value acquisitions and partnerships.

Publisher’s Spotlight: Citeline News And Insights App

 
• By 

Introducing the all-new Citeline News and Insights app, providing seamless access to all your favorite award-winning publications. Explore the latest articles from Pink Sheet, Scrip, In Vivo, Medtech Insight, Generics Bulletin and HBW Insight, all in one stylish, intuitive and user-friendly platform.

More from In Vivo

Clone Test Oncology’s Next Decade: The Therapies And Players Reshaping A $400bn Future - Clone

 

Launching In Vivo’s oncology therapeutic review series, this first instalment provides a data-led primer on the global cancer landscape. Future instalments will explore market dynamics, pipeline evolution and the innovations set to define oncology therapeutics through 2032.

In Vivo’s 2026 Rising Leaders-Part 1

 
• By 

The seventh annual edition of In Vivo’s Rising Leaders features entrepreneurs, academics, lawyers, regulators and innovators from around the globe, representing the forefront of creativity in health care.

XXXXtesting

 
• By 

XXXXtesting