For patients with autosomal dominant polycystic kidney disease (ADKPD), abnormalities in two different genes – PKD1, which accounts for around 78% of cases, and PKD2, which accounts for around 15% – disrupt the regular development of the kidneys and cause cysts to grow, due to abnormally elevated levels of cyclic adenosine monophosphate (cAMP) enzymes.
A person has a 50% chance of developing the condition if one of their parents has one of the faulty...





