Potassium Lowering Therapies Hit NICE Hurdle In UK

 
• By Eleanor Malone
  
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AstraZeneca’s Lokelma and Vifor’s Veltassa will be subject to a final review by the England and Wales health technology appraisal body in December following draft guidance not recommending their use in the National Health Service to treat hyperkalemia.

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AZ and Vifor hope to move NICE roadblock • Source: Shutterstock

AstraZeneca PLC is preparing a “robust response” to draft guidance from NICE, the health technology appraisal body for England and Wales, which recommends against the National Health Service (NHS) using its oral hyperkalemia drug Lokelma (sodium zirconium cyclosilicate). Vifor Pharma Group says it is also preparing a response to NICE’s draft recommendation against the use of its oral hyperkalemia treatment, Veltassa (patiromer).

Hyperkalemia, or high levels of potassium in the blood, is most common in people with chronic kidney disease, heart failure,...

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