CIR Recalculates Parabens Safety Margins; Will Expert Panel’s Confidence Be Shaken?

The Cosmetic Ingredient Review’s newly figured margins of safety for single- and multi-paraben use in cosmetic products are dramatically lower than previous MOSs that informed the Expert Panel’s 2008 “safe as used” conclusions. Whether the panel still deems the MOSs sufficiently protective is the question going into the group’s Sept. 24-25 meeting.

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The Cosmetic Ingredient Review Expert Panel was confident in March that an expanded group of 20 parabens would come out of its re-review with a safe-as-used determination, despite the insufficient data conclusion it posted at the time.

The panel is expected to revisit the subject and issue a tentative amended report Sept. 24-25 in Washington. It remains...

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