Celgene is paying privately held Acceleron Pharma $25 million up front under a deal to jointly develop and commercialise ACE-536, a ligand trap that inhibits members of the transforming growth factor- (TGF) beta "superfamily" involved in the late stages of erythropoiesis – the process of generating red blood cells – as a treatment for anaemia.
Celgene is paying privately held Acceleron Pharma $25 million up front under a deal to jointly develop and commercialise ACE-536, a ligand trap that inhibits members of the transforming growth factor- (TGF) beta "superfamily" involved in the late stages of erythropoiesis – the process of generating red blood cells – as a treatment for anaemia.
Acceleron stands to gain an additional $217 million in milestones under the collaboration, which is the second partnership it has...
A disastrous Phase II miss for the pulmonary arterial hypertension candidate AV-101 leaves Aerovate drifting. Could Gossamer stand to benefit?
2030 sales forecasts for Novo’s obesity hope are an order of magnitude larger than its closest rival among 2025’s expected debutantes.
GLP-1 receptor agonists could play a big role in tackling neurodegeneration and a new academic study has raised expectations of Novo Nordisk’s latest semaglutide Phase III results
CEO Bill Anderson would not be drawn on whether the drug, currently approved for chronic kidney disease associated with type 2 diabetes, will hit a previous forecast of €3bn peak sales, but expansion into heart failure may make that figure look conservative.
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Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.
Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.
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