Alnylam's 'Day After' Revusiran Failure Bad, Maybe Not Catastrophic

 
• By Joseph Haas
  
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Despite its stock price falling 48% 24 hours after the shuttering of lead candidate revusiran, Alnylam is encouraged by analyst reports indicating the failure does not read through to its overall pipeline. The biotech reaffirmed its timeline for its second Phase III candidate patisiran.

Desperate businessmen

The day after announcing it had ended development of its lead candidate revusiran due to an imbalance of deaths in a Phase III trial, Alnylam Pharmaceuticals Inc. took a serious hit on its stock price, but also got reassurance that a broad array of market analysts had determined that because revusiran was substantially differentiated from the rest of Alnylam's RNA-interference pipeline, there probably would be no read-through to the larger portfolio.

Several other publicly traded companies working in the RNA space also saw their share prices decline Oct. 6, but much...

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