Pfizer's Herceptin Biosimilar Moving Forward Amid Rising Competition

Dec 02 2016

• By Sten Stovall

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Pfizer hopes positive top-line Phase III trial data on its Herceptin (trastuzumab) biosimilar can help it tap the lucrative market in HER2-overexpressing cancers, but analysts say that therapeutic space looks increasingly crowded with no clear favorite yet in sight.

Pfizer Inc. Dec. 1 said it was "encouraged" by good top-line results from its Phase III pivotal comparative REFLECTIONS B3271002 study of its PF-05280014 biosimilar for treating patients with HER2-positive metastatic breast cancer. The 690-patient study met its primary endpoint and was designed to measure the safety and efficacy of the biologic follow-on versus Genentech Inc.'s Herceptin (trastuzumab).

Pfizer, which is seeking new sources of revenue growth, said the Phase III trial showed equivalence in the primary end...

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