Heart Failure Pipeline Review: Amgen's Omecamtiv And Merck's Vericiguat Step Up To Plate

 
• By Emily Hayes
  
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In addition to small molecules, stem cell therapies promise to help rejuvenate the chronic heart failure pipeline, but high prices and invasive procedures may limit their use to end-stage patients, and skepticism about efficacy persists.

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Merck & Co. Inc./Bayer AG's soluble guanylate cyclase stimulator vericiguat and Amgen Inc.'s novel inotropic molecule omecamtiv mecarbil, both in Phase III, are each projected to bring in over $1bn in chronic heart failure drug sales in major markets in 2026, accounting for more than one-fifth of total revenue for that year, according to a new pipeline review from Datamonitor Healthcare.

The chronic heart failure (CHF) market is dominated by generics; angiotensin receptor blockers (ARBs) and angiotensin converting enzyme (ACE) inhibitors...

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