Sierra Believes It Can Do Better Than Gilead With JAK Inhibitor Momelotinib

With many on the executive team who worked on the drug previously, Sierra thinks the stalled Phase III compound could be differentiated from Jakafi and others in the myelofibrosis space based on anemia benefit.

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Sierra Oncology Inc. believes it is uniquely positioned to succeed where Gilead Sciences Inc. didn’t with momelotinib in myelofibrosis, by focusing on the benefit demonstrated in clinical trials for addressing anemia and positioning the drug for myelofibrosis patients with or at risk for thrombocytopenia.

The Vancouver biotech acquired the Janus kinase 1/2 (JAK1/2) and activin receptor type 1 (ACVR1) inhibitor for the bargain price...

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