Lilly Moves Closer To NDA Filing For RET Inhibitor In NSCLC

 
• By Joseph Haas
  
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Lilly hopes to bring Loxo’s tissue-agnostic RET inhibitor selpercatinib to market in 2020.

DNA strand and Cancer Cell Oncology Research Concept 3D rendering - Illustration
Lilly is developing Loxo's technology to target cancer on a genetic basis

Eli Lilly & Co.’s $8bn acquisition of Loxo Oncology Inc. in January is looking more like a win as selpercatinib (LOXO-292) posted Phase I/II data in RET fusion-positive non-small cell lung cancer (NSCLC) patients on 9 September that show strong, durable overall responses and progression-free survival as well as a very low rate of discontinuations due to treatment-related adverse events.

Lilly presented the latest data from the ongoing LIBRETTO-001 trial at the World Conference on Lung Cancer (WCLC) in Barcelona,...

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