Merck/Bayer's Vericiguat Could Bring A New Dynamic For Heart Failure

 
• By Jessica Merrill
  
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The Phase III VICTORIA study evaluating the safety of the sGC stimulator met its primary endpoint.

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Vericiguat helped certain patients with chronic heart failure in a Phase III study • Source: Shutterstock

Merck & Co. Inc. and Bayer AG appear to have cleared a major hurdle with positive Phase III data in hand on its soluble guanylate cyclase (sGC) stimulator in development to treat patients with chronic heart failure with reduced ejection fraction (HFrEF). Merck announced on 18 November that the Phase III VICTORIA study evaluating the efficacy and safety of vericiguat met its primary endpoint.

The companies only released topline data from the trial, but said vericiguat reduced the risk of the composite endpoint in...

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