Farxiga CKD Trial Stopped Early For Efficacy, Giving The SGLT2 Inhibitor An Edge

Mar 30 2020

• By Jessica Merrill

Listen to this article

A Phase III trial testing dapagliflozin in chronic kidney disease patients with and without diabetes was stopped early following a recommendation from an independent data monitoring committee.

Business success concept with target as motivation (3D Rendering) — AstraZeneca's Farxiga was successful in chronic kidney disease • Source: Shutterstock

A Phase III study testing AstraZeneca PLC's Farxiga (dapagliflozin) in patients with chronic kidney disease (CKD) will be stopped early due to efficacy, presenting a new commercial opportunity for the sodium glucose cotransporter 2 (SGLT2) inhibitor. The study enrolled patients with and without type 2 diabetes, suggesting a broad opportunity for Farxiga in CKD.

AstraZeneca, announcing the positive trial update on 30 March, said it would begin discussions with global regulatory authorities about the...

More from Genitourinary

Cagrisema Leads The Charge For 2025
Mar 10 2025
• By Elizabeth Cairns
2030 sales forecasts for Novo’s obesity hope are an order of magnitude larger than its closest rival among 2025’s expected debutantes.
Borealis Seeks Aurora In RNA-Based Drugs For Renal Disease
Aug 22 2024
• By Alaric DeArment
With $150m in series A funding, the Versant- and Novartis-backed start-up is betting it can overcome the challenges to getting RNA medicines into the kidney.
Pathalys Raises $105m To Pave Path Toward US Commercialization
Aug 20 2024
• By Mandy Jackson
The start-up launched last year with Phase III-ready upacicalcet, which has nearly completed two pivotal trials in secondary hyperparathyroidism and for which it has exclusive rights outside of Asia.
Quick Listen: Scrip's Five Must-Know Things
Aug 13 2024
• By Ian Haydock
In this week's podcast edition of Five Must-Know Things: Amgen positions for obesity and diabetes; BMS returns TIGIT asset in pipeline reshuffle; is Kerendia the next jewel in Bayer’s crown?; Japan pharma firms cut jobs; and Sun Pharma seeks GLP-1 partner.

More from Therapeutic Category

Scrip Data Article Without An Author
Nov 19 2025
"Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit..."
Spotlight On RDCs, AOCs As Leading Novel Bioconjugates[Updated]
Nov 12 2025
Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.
Fosun ALK/ROS1 Inhibitor Shows 1L Promise In Advanced NSCLC
Nov 12 2025
Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.