Amgen Eschews Some Of Its BiTEs, But Otezla Spurs Growth

Pipeline Changes Planned As Data Evolved

 
• By Mandy Jackson
  
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Without Otezla’s $2.2bn in 2020 sales, Amgen’s full-year revenue would have been slightly lower than in 2019, which is why all eyes are on the company’s R&D programs and near-term approvals.

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Amgen's 2020 revenue of $25.4bn was in line with consensus expectations • Source: Shutterstock

Amgen, Inc. has showcased its bispecific T-cell engager (BiTE) technology as a source of next-generation cancer therapies over the past few years, investing in the platform across a variety of hematological malignancies and tumor types, so it was surprising when the company revealed on 2 February in its fourth quarter 2020 earnings report that it has paused clinical trials and discontinued development for some of its BiTE candidates.

Executive vice president of research and development David Reese told Amgen’s Q4 earnings call that the company always planned to...

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