Incyte Pins Hopes On Phase III Jakafi Analysis In COVID-19 ARDS

Phase III Overall Negative, But Successful On Subset And Post-Hoc Analyses

Drugs for ARDS in COVID-19 have yielded mixed results in the clinic, with Boehringer Ingelheim pulling one from Phase II development earlier this month.

Corona patient
Incyte hopes to gain an expanded access protocol for Jakafi in patients with COVID-19-associated ARDS • Source: Shutterstock

Incyte Corporation is hoping that mixed Phase III data for Jakafi (ruxolitinib) in patients with severe COVID-19 will pass muster with the US Food and Drug Administration and lead to its availability under compassionate use. But the disease area it is attempting to tackle has been a difficult one.

The Wilmington, DE-based drug maker announced 18 March results from the placebo-controlled Phase III DEVENT trial comparing the JAK inhibitor...

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