Genfit’s Post-NASH Plans Center On ACLF, Cholestatic Liver Disease

 
• By Joseph Haas
  
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After last year’s Phase III failure in NASH, Genfit sees big opportunity in acute on chronic liver failure (ACLF), potentially with antiviral NTX. Its ongoing Phase III program in PBC as also is a potential revenue-driver.

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Genfit is moving on from NASH, into rare liver indications

One year after its Phase III failure in non-alcoholic steatohepatitis (NASH) with elafibranor, Genfit SA outlined its new R&D focus for investors on 11 May, headlined by a strategy to test a now-generic anti-infective drug in acute on chronic liver failure (ACLF). The French firm’s focus also remains on a pivotal Phase III study of elafibranor in second-line primary biliary cholangitis (PBC), as well as plans to test the drug and a second internally discovered PPAR agonist in first-line PBC as well as primary sclerosing cholangitis (PSC).

Genfit held out hope for bringing elafibranor, an agonist of the PPAR alpha and delta receptors, to market for NASH...

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