Novartis COVID-19 Therapy Could Overcome Escape Variant Problem

Protein Therapeutic Enters Pivotal Trial

The DARPin candidate will not gain emergency approval before early 2022, but its likely ability to sustain efficacy regardless of SARS-CoV-2 mutations could be valuable as new variants emerge.

Novartis
Novartis is using a novel Phase II/III trial design to produce fast results in patients with early stage COVID-19 infections.

Novartis and Molecular Partners have begun a pivotal trial of novel therapy ensovibep (MP0420) to see if it can prevent people with early-stage COVID-19 from worsening symptoms and being hospitalized.

Ensovibep is a novel DARPin therapeutic, a new drug class which is being developed by Molecular Partners, a Switzerland-based biotech...

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Spotlight On RDCs, AOCs As Leading Novel Bioconjugates[Updated]

Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.

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EHA: Lilly’s Jaypirca Posts First Phase III Triplet Win In CLL While BTK Degraders Advance

Lilly's first Phase III triplet win opens the door to a label expansion in BTK-pretreated CLL, with analysts suggesting Jaypica could attain blockbuster status. However, the window to capitalize may be brief as next-generation BTK degraders close in with head-to-head trials.

EHA: Lilly’s Jaypirca Posts First Phase III Triplet Win In CLL While BTK Degraders Advance - Clone

Lilly's first Phase III triplet win opens the door to a label expansion in BTK-pretreated CLL, with analysts suggesting Jaypica could attain blockbuster status. However, the window to capitalize may be brief as next-generation BTK degraders close in with head-to-head trials.