The antiplatelet drug-reversal agent could see uptake grow in tandem with that of Brilinta, but there is a history of drugs in similar indications underperforming on the market.
PhaseBio Pharmaceuticals, Inc. is hoping that growing use of AstraZeneca plc’s blood thinner Brilinta (ticagrelor) as it goes generic, plus a clean safety profile and user-friendly formulation, will drive uptake of its Brilinta-reversal agent bentracimab. But there is also a history of reversal agents used in parallel clinical situations not performing well.
PhaseBio presented data on 15 November at the American Heart Association annual meeting from a prespecified interim analysis of 150...
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US FDA approval of Niktimvo for third-line chronic GVHD, a competitor to Sanofi’s Rezurock, came less than two months ahead of anticipated approval of Syndax’s leukemia drug revumenib.
The company’s giroctocogene fitelparvovec, partnered with Sangamo, could compete with BioMarin’s hemophilia A gene therapy Roctavian, but longer-term data may be needed.
2seventy bio sold full rights to a hemophilia A program and in vivo gene editing technology to partner Novo Nordisk.
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Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.
Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.
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