ESMO: Gilead’s Trodelvy Outperforms Expectations In Breast Cancer, Again

 
• By Alaric DeArment
  
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The company is presenting overall survival data in HR+/HER2- breast cancer from the TROPiCS-02 at ESMO. Oncology clinical development head Bill Grossman talked with Scrip about how it differs from rival Enhertu.

OS data from Gilead's TROPiCS-02 trial exceeded the expectations of many investors • Source: Shutterstock

Gilead Sciences, Inc.’s anti-TROP2 antibody-drug conjugate Trodelvy (sacituzumab govitecan-hziy) beat expectations as data from the Phase III TROPiCS-02 study showed a statistically significant improvement on overall survival among patients with HR-positive/HER2-negative metastatic breast cancer. It also compared more favorably to data for the drug’s top competitor, AstraZeneca plc and Daiichi Sankyo Co., Ltd.’s HER2-targeting Enhertu, than previously thought.

The company released the data on 7 September, which it plans to present at the European Society for Medical Oncology...

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