ESMO: Relay’s RLY-4008 Shows High Response, Lower Toxicity In Cholangiocarcinoma

 
• By Alaric DeArment
  
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The new data bolster the company’s hypothesis that more specific targeting of FGFR2 can overcome the toxicity limitations of other FGFR inhibitors.

Relay Therapeutics presented data for RLY-4008 in cholangiocarcinoma at ESMO • Source: Shutterstock

Relay Therapeutics, Inc. has bolstered its case that more precise targeting of fibroblast growth factor receptor 2 (FGFR2) can overcome the limitations of existing FGFR inhibitors in FGFR2-altered cholangiocarcinoma by sidestepping the off-target toxicities associated those drugs, particularly hyperphosphatemia and diarrhea. While the dataset includes only a small number of patients and the median duration of response remains unreached, there were encouraging signs, including a high response rate.

Relay presented the highly anticipated data at the European Society for Medical Oncology meeting on 11 September for RLY-4008, its...

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