Vertex Adds To Myotonic Dystrophy Effort With Entrada Collaboration

 
• By Joseph Haas
  
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Entrada gets $250m cash and equity up front under four-year deal, which extends its runway and will enable it to focus on Duchenne muscular dystrophy. Vertex further diversifies its pipeline with a novel drug class.

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Vertex continues its diversification strategy with Entrada alliance • Source: Shutterstock

Vertex Pharmaceuticals Incorporated has experience shifting focus, having transitioned rapidly from a hepatitis C specialist to its current concentration on cystic fibrosis, and its 8 December collaboration with Entrada Therapeutics, Inc. will help it increase its efforts in myotonic dystrophy type 1 (DM1). Entrada gets $224m in cash up front under the agreement, along with a $26m equity investment priced at $16.26 per share, roughly a 5% premium on the biotech’s 10-day stock price average.

Under the deal, Vertex acquires preclinical ENTR-701, an intracellular endosomal escape vehicle (EEV) believed to address the underlying cause of...

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