Pfizer joined Novartis as the market leader in sickle cell disease when it acquired Global Blood Therapeutics last year. The US giant's Oxbryta may now move ahead following a clinical and regulatory setback for the Swiss major's Adakveo.
Novartis AG's hopes of Adakveo becoming a blockbuster have taken a hit with the news that the already-approved sickle cell disease therapy has failed a late-stage trial and is being reviewed by the European Medicines Agency.
On 27 January, the Swiss major said that preliminary results from the Phase III STAND trial of Adakveo (crizanlizumab) found...
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2seventy bio sold full rights to a hemophilia A program and in vivo gene editing technology to partner Novo Nordisk.
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Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.
Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.
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