Biohaven Makes Bet On Brain-Penetrant TYK2/JAK1 Inhibitor For Neurological Diseases

The company, which has struggled in the clinic following a deal where Pfizer bought its migraine portfolio, is licensing the dual inhibitor drug from a Chinese firm for up to $970m.

Biohaven and Higlightll signed a licensing deal worth up to $970m for Highlightll's brain-penetrant TYK2/JAK1 inhibitor • Source: Shutterstock

Biohaven Ltd. is plunking down $20m up front and in a licensing deal worth up to $950m in milestones fees to access a Chinese biotech company’s preclinical dual inhibitor of TYK2 and JAK1 in the hope of developing it for neurodegenerative and neuroinflammatory disorders while sidestepping the class-effect toxicity often associated with inhibitors of JAK2 and JAK3.

The deal represents a continued effort on the part of Biohaven to branch out into new frontiers of neurology after...

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