ASCO 2023 – A Role For Immuno-Oncology In Ovarian Cancer At Last?

  
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AstraZeneca’s Duo-O trial suggests that excluding Brca-positive patients could be the key to Imfinzi’s apparent success in ovarian cancer.

Ovary
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AstraZeneca PLC appears to have teased out a positive result for Imfinzi in ovarian cancer – a setting that so far has proved intractable for anti-PD-(L)1 drugs. The data, toplined positive in April, concern the Duo-O study of an Avastin/Imfinzi/Lynparza triplet, and have been presented 3 June as an American Society of Clinical Oncology (ASCO) late-breaker.

The result is notable for having apparently succeeded where other PD-(L)1/Parp inhibitor combinations have failed, and one reason for this...

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