ASCO: AstraZeneca’s ADRIATIC Passes One Test, With One More To Go

 
• By Alaric DeArment
  
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The results for Imfinzi mark the first significant advance in LS-SCLC in four decades, but will the combination with Imjudo succeed after flopping in CASPIAN?

• Source: Scrip

A setting of small-cell lung cancer (SCLC) that has not seen its standard-of-care treatment change since the 1980s is poised to enter the immunotherapy era based on positive results from a study using AstraZeneca PLC’s PD-L1 inhibitor Imfinzi (durvalumab). But while it marks a major advance, the track record of adding AstraZeneca’s CTLA-4 inhibitor Imjudo (tremelimumab-actl) has not shown the same level of success.

Data from the Phase III ADRIATIC study comparing Imfinzi against placebo in limited-stage SCLC (LS-SCLC) were presented on 2 June...

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