Amgen, Inc.’s Imdelltra (tarlatamab) for extensive-stage small cell lung cancer (ES-SCLC) is one of only two bispecific T-cell engagers (BiTEs) approved in the US to treat solid tumors. As additional DLL3-targeting BiTEs near the market, those drugs may benefit from doctors’ earlier experience learning to manage adverse events for BiTEs and other T-cell recruiters – chiefly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS)
Clinical trial results were presented at the recent World Conference on Lung Cancer (WCLC) for Imdelltra and two other DLL3...
