Onconova Therapeutics plunged 37.4% in after-hours trading to $8.68 per share on 19 February after the company said its PI3K and PLK inhibitor rigosertib failed in the Phase III ONTIME clinical trial in high-risk myelodysplastic syndromes (MDS).
It was the second late-stage failure for rigosertib in two months. The Newtown, Pennsylvania-based company discontinued a Phase III pancreatic...






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