Sciwind Eyes Differentiation For Ecnoglutide In Highly Competitive Arena

cAMP Bias Benefits?

 
• By Xu Hu
  
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Chinese firm Sciwind has revealed additional Phase III findings for its promising once-weekly GLP-1 agonist ecnoglutide, just one asset in a burgeoning Chinese sector that could see the emergence of new rivals to current global leaders in obesity and diabetes.

China's Sciwind progresses obesity candidate • Source: Shutterstock

With some Phase III clinical and real-world evidence showing superior effects on HbA1c reduction in type 2 diabetes and on weight loss for GLP-1/GIP analogs, such as Eli Lilly and Company’s tirzepatide, that favor the cAMP signaling pathway over β-arrestin recruitment, one Chinese developer is now hoping its similarly acting contender may benefit from the same differentiation.

Hangzhou-based Sciwind Biosciences Co., Ltd. has mentioned in published research papers that its long-acting, cAMP signaling biased GLP-1 analog...

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