Drug Name

Lead Company

Target

Current Phase

Lead Indication

Likelihood of Approval

Molecule

Gantenerumab

Roche Holding AG

Amyloid Beta/Amyloid Plaques

II/III

Y

9% (43% Below Avg.)

Monoclonal Antibody

Albutein + Flebogamma DIF

Grifols, S.A.

Amyloid Beta/Amyloid Plaques

II/III

Y

52% (Same As Avg.)

Protein

AZD3293

AstraZeneca PLC

Beta-secretase (BACE)

II/III

Y

52% (Same As Avg.)

Small Molecule

BAN2401

Eisai Co., Ltd.

Amyloid Beta/Amyloid Plaques

IIb

Y

16% (1% Below Avg.)

Monoclonal Antibody

NIC5-15

Humanetics Corporation

Gamma-secretase

IIb

Y

17% (Same As Avg.)

Small Molecule

Sembragiline

Evotec AG

Monoamine oxidase B (MAO-B)

IIb

Y

7% (10% Below Avg.)

Small Molecule

Aducanumab

Biogen, Inc.

Amyloid Beta/Amyloid Plaques

III

Y

53% (1% Above Avg.)

Monoclonal Antibody

ALZT-OP 1

AZTherapies, Inc.

Amyloid Beta/Amyloid Plaques

III

Y

52% (Same As Avg.)

Small Molecule

Crenezumab

Roche Holding AG

Amyloid Beta/Amyloid Plaques

III

Y

45% (7% Below Avg.)

Monoclonal Antibody

Solanezumab

Eli Lilly & Company

Amyloid Beta/Amyloid Plaques

III

Y

16% (36% Below Avg.)

Monoclonal Antibody

MK-8931

Merck & Co., Inc.

Beta-secretase (BACE)

III

Y

53% (1% Above Avg.)

Small Molecule

Masitinib

AB Science S.A.

Fibroblast Growth Factor Receptor (FGFR)^ KIT/c-KIT^ Platelet-derived growth factor receptor (PDGFR)

III

N

52% (Same As Avg.)

Small Molecule

Encenicline

FORUM Pharmaceuticals, Inc.

Nicotinic Acetylcholine Receptor - a7 subtype
(a7 nAChR)

III

N

51% (1% Below Avg.)

Small Molecule

AVP-786

Otsuka Holdings Co., Ltd.

NMDA Glutamate Receptor

III

N

52% (Same As Avg.)

Small Molecule

Actos

Takeda Pharmaceutical Company Ltd

PPAR gamma

III

N

52% (Same As Avg.)

Small Molecule

Azeliragon

vTv Therapeutics Inc.

Receptor for Advanced Glycation End Products (RAGE)

III

Y

52% (Same As Avg.)

Small Molecule

Rexulti

Otsuka Holdings Co., Ltd.

Serotonin 5-HT2A receptor

III

N

52% (Same As Avg.)

Small Molecule

Idalopirdine

H. Lundbeck A/S

Serotonin 5-HT6 receptor

III

N

56% (4% Above Avg.)

Small Molecule

RVT-101

Axovant Sciences, Inc.

Serotonin 5-HT6 receptor

III

Y

55% (3% Above Avg.)

Small Molecule

LMTX

TauRx Therapeutics Ltd.

Tau proteins

III

N

49% (3% Below Avg.)

Small Molecule

AC-1204

Accera, Inc.

Tricarboxylic Acid (TCA) Cycle/Citric Acid Cycle (CAC)

III

Y

52% (Same As Avg.)

Small Molecule

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