Atopic Dermatitis: Ziarco Hopes Oral Therapy Will Trump Injectable Biologics

 
• By John Davis
  
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UK biotech Ziarco’s orally active histamine H4-antagonist shows potential in atopic dermatitis in proof-of-concept studies, and the firm may seek capital for further studies before it is Phase III ready.

Pfizer Inc. spin-out Ziarco Pharma Ltd. released positive proof-of-concept Phase IIa data for its novel histamine H4 antagonist ZPL-389 in moderate-to-severe atopic dermatitis on May 16, that suggest it could have potential advantages over other investigational therapies for the condition, such as Sanofi/Regeneron Pharmaceuticals Inc.’s biologic therapy dupilumab.

Histamine antagonists have been a fruitful area of research for many pharmaceutical companies over the years including the past development...

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