Positive Tagrisso Data Boost AstraZeneca's Lung Cancer Ambitions

 
• By Sukaina Virji
  
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Latest data from AstraZeneca's Tagrisso will help the company to convert the lung cancer drug's conditional approvals to full approvals, and boost reimbursement negotiations.

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AstraZeneca's Phase III AURA3 trial has met its primary endpoint, demonstrating better progression-free survival (PFS) compared to standard platinum-based doublet chemotherapy. The AURA3 randomized trial assessed the efficacy and safety of Tagrisso (osimertinib) as a second-line treatment in more than 400 patients with EGFR T790M mutation-positive, locally-advanced or metastatic NSCLC, whose disease had progressed following first-line EGFR tyrosine kinase inhibitor (TKI) therapy. Tagrisso also demonstrated a safety profile consistent with previous trials.

"[This data] means that AstraZeneca can now move to file for full approval of this treatment in the US and...

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