GSK's Nucala Shows Promise In A Rare Systemic Vasculitis

 
• By John Davis
  
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GlaxoSmithKline is cementing its leadership position in eosinophilic conditions with promising pivotal results with Nucala as an add-on therapy for the rare disorder eosinophilic granulomatosis with polyangiitis. The development is expected to lead to an extension of its indications.

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Artery structure • Source: Shutterstock

GlaxoSmithKline PLC plans to submit approval applications next year for the use of Nucala (mepolizumab) in patients with eosinophilic granulomatosis with polyangiitis (EGPA), after the IL-5 antagonist MAb met its endpoints in a pivotal Phase III study that is part of a collaboration between GSK and the US National Institute of Allergy and Infectious Diseases on developing drugs for rare diseases.

The Phase III study, dubbed MEA115921, is the first double-blind placebo-controlled trial to be conducted in EGPA, an extremely rare...

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