Triple Immunotherapy Combos Enter The Ovarian Cancer Fight

 
• By John Davis
  
Generate a summary of this article
Listen to this article
Beta

Immunovaccine’s investigational cancer vaccine combined with an immunomodulator and a checkpoint inhibitor or other similar type of agent could have a synergistic beneficial effect on tumor cells, and lead to triple-drug combinations being evaluated in other cancers.

Supplement

Numerous clinical studies of dual combinations of checkpoint inhibitors are underway, with or without conventional chemotherapy agents, but one of the first Phase Ib studies of a triple combination of immunotherapies in ovarian cancer that includes an investigational cancer vaccine is expected to report initial results in March 2017, and a Phase II trial of another similar triple combination should start in the next several months.

Both triple combinations involve Immunovaccine Inc.’s potential cancer vaccine DPX-Survivac to induce T-cell activation, low doses of cyclophosphamide that...

Scrip Podcast

Keep up with the top pharma business news of the week. On the go.

Scrip brings you a weekly bulletin of top picks.

SpotifyApple PodcastsWebsite

More from Clinical Trials

  • Sciwind Eyes Differentiation For Ecnoglutide In Highly Competitive Arena

     
    • By Xu Hu

    Chinese firm Sciwind has revealed additional Phase III findings for its promising once-weekly GLP-1 agonist ecnoglutide, just one asset in a burgeoning Chinese sector that could see the emergence of new rivals to current global leaders in obesity and diabetes.

  • Fosun ALK/ROS1 Inhibitor Shows 1L Promise In Advanced NSCLC

     
    • By Xu Hu

    Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.

  • Sponsored By:

    Nancy Tests SPARC-931-part

    The article discusses the impact of upcoming patent expirations in oncology biologics on biosimilar developers, highlighting the opportunities in Antibody-Drug Conjugates (ADCs) and Bispecific Antibodies (BsAbs). It explores the challenges posed by the structural complexities of these biologics, necessitating new bioanalytical tools and manufacturing processes. The evolving regulatory landscape, with contributions from EMA, FDA, and WHO, offers flexible pathways but also presents challenges. The article underscores the potential for biosimilars to generate significant cost savings and enhance patient access to cancer treatments over the next decade.

  • Fosun ALK/ROS1 Inhibitor Shows 1L Promise In Advanced NSCLC

    Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.

More from R&D