CSL Behring Nears Market With Easier-To-Administer HAE Prophylactic

 
• By John Davis
  
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CSL Behring’s long-acting subcutaneous C1 inhibitor formulation, CSL830, has confirmed its efficacy for the prevention of hereditary angioedema (HAE) attacks, and is expected to be introduced this year, giving it initial traction in what could become a crowded sector.

Edema

The results of the CSL Behring-sponsored Phase III COMPACT (clinical study for optimal management of preventing angioedema with low volume subcutaneous C1-inhibitor replacement therapy) trial showed that twice-weekly, self-administered subcutaneous injections of CSL830 were associated with a significant reduction in the frequency of acute HAI attacks, compared with placebo, with only mild and transient adverse effects.

“More than 50% of patients had no moderate-to-severe attacks while they were receiving CSL830,” noted UK clinical researcher Hilary Longhurst...

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