Incyte Eyes Big Phase III IDO Expansion, NewLink Plans First Pivotal Trial

May 04 2017

• By Emily Hayes

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NewLink is hoping FDA will accept its plans to run one Phase III registrational study of its IDO pathway inhibitor indoximod with an anti-PD-1 agent in frontline melanoma; Incyte updates its Phase III plans for epacadostat.

First-quarter earnings calls on May 4provided an opportunity forIncyte Corp. to highlight the breadth of the multi-tumor registrational program for its leading IDO inhibitor epacadostat and for NewLink Genetics Corp.to share its plans to test its IDO pathway inhibitor indoximod in a pivotal melanoma study, which is set to kick off by the end of the year.

Incyte Corp.'s epacadostat is the most advanced candidate for one of the hottest new immunotherapy targets in development: indoleamine 2,3-dioxygenase...

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