Alzheimer's Prevention: The Next Big Idea For Fixing Drug Trial Failures

Mass screening of asymptomatic people is an expensive, daunting proposition, but very preliminary research with an amyloid beta blood test is spurring hope that a more practical way to identify those at risk will emerge in the future.

Someone is erasing a drawing of the human brain. Conceptual image relating to dementia and memory loss. Digital illustration.

Faced with continuing failure in Alzheimer’s drug development, researchers are grappling with the best route forward. And as efforts to modify disease progression or even better symptomatic treatment disappoint, despite the best efforts of giants in the biopharma industry, there is growing recognition of the need to move even earlier in Alzheimer’s disease – toward prevention.

Heading off the degenerative disease, maybe even 10 or 20 years before symptoms develop, is an intriguing idea, though some...

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