Vertex Cystic Fibrosis Forecast Brightens, With Gloomy Prospects For Competition

 
• By Joseph Haas and John Davis
  
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Vertex continued its growth story in cystic fibrosis during 2017. It also chose a pair of candidates for Phase III triple combination development, threatening to virtually seal off market entry to others.

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The performance of Vertex Pharmaceuticals Inc.'s cystic fibrosis portfolio was strong coming out of 2017, and analysts' rave reviews about the potential for triple-therapy combinations the specialty pharma plans to bring into pivotal trials during 2018 spurred speculation of shutting other companies – namely the partnership of AbbVie Inc. and Galapagos NV – out of the CF market entirely.

Out of four next-generation cystic fibrosis transmembrane conductance regulator (CFTR) correctors Vertex moved into Phase II, VX-659 and VX-445 were...

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