Regeneron And Teva's Fasinumab Crosses One Threshold; More Remain

 
• By Jessica Merrill
  
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The companies reported positive Phase III data testing the nerve growth factor inhibitor in patients with chronic pain, but the efficacy appears modest and safety will remain a question until long-term Phase III data read out. The companies are focused on a lower 1 mg dose.

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Partners Regeneron Pharmaceuticals Inc. and Teva Pharmaceutical Industries Ltd. slightly trail rivals Pfizer Inc. and Eli Lilly & Co. in reporting the first positive Phase III data on a potential new class of drugs for pain – nerve growth factor (NGF) inhibitors – revealing on Aug. 16 that their ant-NGF candidate fasinumab significantly reduced pain compared to placebo. But as with Pfizer/Lilly's tanezumab, fasinumab's safety will remain a big focus as additional trials read out.

Fasinumab's efficacy data, while significant, appears modest versus placebo, which could present more challenges when it comes to commercializing a...

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