Lilly Advances IL-23, Gastroenterology Ambitions With Mirikizumab In Crohn's Disease

 
• By Mandy Jackson
  
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The company reported positive Phase II results and will move its potential fourth-to-market IL-23 inhibitor into Phase III in Crohn's disease later this year. Mirikizumab – in Phase III for psoriasis and ulcerative colitis – may be the second IL-23 drug for an IBD indication.

Crohn's disease (gastrointestinal disease) diagnosis medical concept on tablet screen with stethoscope. - Image
Mirikizumab could be the second IL-23 inhibitor for IBD indications. • Source: Shutterstock

Eli Lilly & Co. is in the running to bring a fourth interleukin-23 (IL-23) inhibitor to market and reported Phase II results on 21 May for its candidate mirikizumab in Crohn's disease. It's the second inflammatory bowel disease (IBD) that Lilly's pursuing, in addition to ulcerative colitis – a pair of indications that could give it an edge in a crowded IL-23 field, though competitors also are moving ahead in the space.

Lotus Mallbris, vice president of immunology development, told Scrip that while gastroenterology is a relatively new therapeutic area for Lilly,...

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