Opening The Door For Cell Therapy In Solid Tumors

 
• By Daniel Chancellor
  
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The next frontier for cell therapy is solid tumors – and of the many attempts to move from liquid to solid tumors, tumor infiltrating lymphocytes and other CAR-T constructs are some of the most promising. 

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Several groups shared research at ASCO for new CAR-T designs in well-defined subgroups of patients with solid tumors that have failed previous conventional therapies. • Source: Shutterstock

The first wave of chimeric antigen receptor T-cell (CAR-T) therapies – the CD19-targeted Kymriah from Novartis and Yescarta from Gilead – are now being established in the blood cancers acute lymphoblastic leukemia and diffuse large B-cell lymphoma, respectively, and attention has turned towards different CAR-T constructs and other cell therapy approaches that may show promise in the much larger solid tumor setting.

Over 90% of cancers arise from solid organs, but so far the development of effective cell therapies for these tumors...

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