Gilead Moves On From Selonsertib, Looks To ATLAS To Map Its NASH Future

 
• By Joseph Haas
  
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Gilead detailed its Phase III failure with ASK1 inhibitor selonsertib in NASH, but anticipates finding a new regimen to take into Phase III in NASH with the ATLAS combination study data expected in December.

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Gilead presents the full Phase III dataset for selonsertib at AASLD 2019

Even though the STELLAR 3/STELLAR 4 trials of Gilead Sciences Inc.’s non-alcoholic steatohepatitis (NASH) candidate selonsertib failed to show a reduction in fibrosis, the company calls the studies a valuable learning tool that will inform its continuing work on bringing a NASH drug to market – and will augment the Phase III data coming soon from the ATLAS study of the firm’s other NASH candidates.

“The results weren’t what we were hoping for, but I think it’s an extremely rich resource in terms of serum...

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