ResTORbio Pins Hopes On Parkinson’s After Failed CSRI Study

Investors Seem Wary Of Its Prospects, However

 
• By Leah Samuel
  
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Company terminates studies of its TORC1 blocker after it fails to prevent respiratory illness in elderly patients with clinically symptomatic respiratory illness (CSRI). ResTORbio is hoping the same drug will be effective in Parkinson’s disease.

Desperate businessmen
RTB101 failed first trial, second trial stopped • Source: Shutterstock

After ResTORbio Inc.’s RTB101 failed to meet the primary endpoint in the first of two Phase III studies, the company immediately cancelled the second study, abandoning the lead indication of clinically symptomatic respiratory illness (CSRI). It is now focusing purely on developing the drug for Parkinson’s disease, but the decision did not appear to appease investors.

“Specifically, we have a Phase Ib/IIa ongoing study of RTB101 alone and in combination with sirolimus in Parkinson's disease that...

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