Apellis Comes Closer To Taking On Alexion In PNH

 
• By Leah Samuel
  
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Besting Alexion’s Soliris in a head-to-head Phase III trial portends a place in the market for Apellis’ competitor in paroxysmal nocturnal hemoglobinuria. But challenges dog both companies.  

3-D Rendering Red Blood Cells
Pegcetacoplan beat Soliris in head-to-head study

Cautious optimism greeted the Apellis Pharmaceuticals Inc. announcement of positive Phase III results for its paroxysmal nocturnal hemoglobinuria (PNH) drug pegcetacoplan, including beating Alexion Pharmaceuticals Inc.’s standard of care Soliris (eculizumab), though analysts raised concerns about the product’s safety profile and want to see more detailed results to better understand the significance of the findings.

Apellis’ pegcetacoplan (APL-2) is a pegylated derivative of the cyclic tridecapeptide compstatin and inhibits complement component (C3) activation. It could...

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