Immunomedics’ ASCENT Confirms Trodelvy’s Efficacy In Triple-Negative Breast Cancer

 
• By Mandy Jackson
  
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After accelerated approval in the US in April based on Phase II response rates, the company will seek full approval later this year based on a tripling of progression-free survival in a Phase III trial.

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Trodelvy could find its way to more TNBC patients based on Phase III data • Source: Shutterstock

Immunomedics, Inc. reported top-line results from the Phase III ASCENT clinical trial on 6 July for Trodelvy in which progression-free survival (PFS) was three times as long for patients with previously treated metastatic triple-negative breast cancer (TNBC) who were treated with the antibody-drug conjugate (ADC) targeting Trop-2 compared with patients who received chemotherapy. More detailed results could improve uptake and reimbursement for the recently launched product.

Trodelvy (sacituzumab govitecan-hziy) received accelerated US Food and Drug Administration approval in April for the treatment of metastatic TNBC patients...

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