Takeda/Ovid Plan Phase III For Soticlestat In Dravet Syndrome, But Pull Back On LGS

 
• By Jessica Merrill
  
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A Phase II trial of the CH24H inhibitor showed a statistically significant benefit in children with the rare epilepsy syndrome Dravet Syndrome, but not in Lennox-Gastaut syndrome (LGS).

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Ovid/Takeda reported mixed Phase II data in rare epilepsies • Source: Shutterstock

A Phase II trial testing Takeda Pharmaceutical Company Limited. and Ovid Therapeutics, Inc.'s first-in-class enzyme cholesterol 24-hydroxylase (CH24H) inhibitor soticlestat in children with the rare developmental and epileptic encephalopathies (DEEs) Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) has yielded mixed results, so the partners are moving forward with a Phase III trial in DS but pulling back on LGS to further analyze the results.

Takeda and Ovid announced the top-line data from the Phase II ELEKTRA study on 25 August, with the trial meeting...

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