Mesoblast Still Hopes To Show Utility Of Allogeneic Stem Cell Therapy In COVID-19

 
• By Joseph Haas
  
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Although its 300-patient, Phase III trial is not likely to reduce mortality, Australian firm says the full dataset may show potential for off-the-shelf cell therapy in acute respiratory distress syndrome.

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Mesoblast was unable to replicate earlier data in treating COVID-19 infections

A year of disappointments continued for Mesoblast Limited on 17 December as a data safety monitoring board advised the company that its Phase III study of remestemcel-L in COVID-19-related acute respiratory distress syndrome (ARDS) was unlikely to meet its primary endpoint. The Australian firm and partner Novartis AG are heeding the advice to stop enrolling new patients, but Mesoblast said it still hopes a full review of the data including secondary endpoints may indicate a path forward for the stem cell therapy in COVID-19 patients.

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