Horizon Will Submit Krystexxa sBLA To Strengthen Clinical Profile In Gout

 
• By Jessica Merrill
  
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A clinical trial confimred Krystexxa in combination with methotrexate increased response rates in patients with uncontrolled gout.

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Horizon sees a new opportunity to expand Krystexxa to more patients • Source: Alamy

Horizon Therapeutics plc has an ambitious goal to turn its gout therapy Krystexxa (pegloticase) into a $1bn brand and now has data to support an enhanced clinical profile for the drug in uncontrolled gout. The company announced on 25 October that the Phase IV MIRROR clinical trial testing Krystexxa in combination with the immunomodulator methotrexate showed significantly improved efficacy compared to treatment with Krystexxa alone in chronic refractory gout.

Improving Krystexxa's clinical profile has been a core part of Horizon's growth strategy for the brand since the company acquired...

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