Chinese firm Kintor disclosed findings from a pivotal Phase III trial showing its androgen receptor antagonist proxalutamide achieved a 50% reduction in risk of hospitalization or death in COVID-19 patients with mild-to-moderate infection, although uncertainty remains over it being “unable to provide” a p-value in some data analyses.
Hong Kong-listed Kintor Pharmaceutical Ltd. on 6 April released top-line results from a placebo-controlled, pivotal clinical trial to study its oral COVID-19 antiviral proxalutamide, marking one of the first attempts by a Chinese firm to investigate such a candidate in an international Phase III study.
A repurposed androgen receptor-targeting prostate cancer drug, proxalutamide was studied in 733 non-hospitalized patients enrolled from April to December 2021,...
A framework to end the Iran war is in place but fractured supply chains can’t recover overnight. Data from India suggests solvent prices have generally cooled from April peaks, but API costs stay elevated or even climbed in June for some products.
Already one of the world’s largest pharmaceutical markets, China has tremendous growth potential, but significant policy and market changes are rocking the basis of competition. Multinational biopharma corporations cannot succeed in this new environment unless they fundamentally reinvent their business models to adapt to sweeping change.
Pipelines in bioconjugates continue to develop, from ADCs to XDCs, with radionuclide drug conjugates (RDCs) and antibody-oligonucleotide conjugates (AOCs) leading the expansion.
Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.
A court order encompassing funding, drug pricing, clinical trials and overall policy implementation aspects is expected to bring about a paradigm shift in the treatment of rare diseases in India. Sarepta, Roche and Sanofi are among the key players that have been part of pricing discussions.
The nod will help unlock a national market for the partners’ Dupert (fulzerasib) in which roughly 50,000 people are expected to be newly diagnosed with lung cancer harboring the KRAS G12C mutation in 2025. Meanwhile, two other homegrown rivals are also closing in on marketing clearances in China.
Amgen’s Imdelltra for small-cell lung cancer is one of two bispecific T-cell engagers approved for solid tumors, but data at the WCLC meeting show other DLL3-targeting BiTEs may be on the way.
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