Spine Takes Yuhan’s Peptide Into US Phase III For High-Need DDD

Second Asset In Global Pivotal Trials

 
• By Jung Won Shin
  
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Major Korean firm Yuhan is seeing progress across multiple novel drug candidates licensed out to global partners, with two now entering pivotal trials. An innovative therapy for degenerative disc disease licensed to Spine BioPharma has received an FDA nod for a Phase III program and may change the standard of care for chronic low back pain patients.

back pain
Treatment Aims To Change Standard Of Care For CLBP patients • Source: Alamy

Yuhan Corporation’s first-in-class novel peptide drug candidate for degenerative disc disease (DDD), licensed out to US company Spine BioPharma in 2018, is now set to move into a Phase III trial in the US, marking the South Korean pharma firm’s second global pivotal stage program following the novel lung cancer drug lazertinib, being developed by Janssen Pharmaceutical Cos.

YH14618 (coded SB-01 by Spine) is a 7-amino acid chain peptide that binds to and induces down-regulation of transforming growth...

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