Biohaven’s Life Without CGRP Inhibitors Gets Off To A Rocky Start

Data Mixed In Spinocerebellar Ataxia Study, But Zavegepant PDUFA Date Set

 
• By Mandy Jackson
  
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With the sale of its migraine portfolio to Pfizer pending, Biohaven said troriluzole – a lead asset in the pipeline soon to be spun out in a new company – failed in a Phase III trial. 

Exotic rocky road to the crater of the volcano in the famous Caldera of Santorini island
The road to clinical success outside of its CGRP pipeline always has been rocky for Biohaven • Source: Shutterstock

Biohaven Pharmaceutical Holding Company Ltd. said 23 May that troriluzole did not meet the primary endpoint versus placebo in a Phase III clinical trial in spinocerebellar ataxia (SCA) but is holding out hope that the US Food and Drug Administration will endorse a path forward for a subgroup of patients. Still riding high from Pfizer Inc.’s recently announced $11.6bn acquisition of the company’s migraine therapy portfolio, however, Biohaven did not take a big hit from the setback.

The company also announced news the same day that was good for both Biohaven and its acquirer – the FDA...

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