Amgen’s Lumakras Succeeds In Confirmatory Lung Cancer Trial

Detailed Results To Be Presented Later

 
• By Mandy Jackson
  
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Amgen said its KRAS G12C inhibitor Lumakras (sotorasib) bested docetaxel in a Phase III clinical trial on the primary endpoint of progression-free survival in second-line-plus non-small cell lung cancer.

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Amgen has multiple monotherapy and combination therapy studies of Lumakras under way in lung and other cancers • Source: Shutterstock

It appears that Amgen, Inc.’s first-to-market KRAS G12C inhibitor Lumakras (sotorasib) has the data it needs for full approval in the US after the drug succeeded in a Phase III clinical trial in previously treated patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC). The study is meant to serve as a confirmatory trial following accelerated approval of Lumakras in May 2021 as a second-line treatment.

Amgen said on 30 August that Lumakras monotherapy bested docetaxel chemotherapy in the Phase III CodeBreaK 200 trial, demonstrating statistical...

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